• April 3 – Detroit at Sox* 6-3 L
  • April 5 – Detroit at Sox
  • April 6 – Detroit at Sox
  • April 7 – Minnesota at Sox
  • April 8 – Minnesota at Sox
  • April 9 – Minnesota at Sox
  • April 11 – Sox at Cleveland
  • April 12 – Sox at Cleveland
  • April 13 – Sox at Cleveland
  • April 14 – Sox at Minnesota
  • April 15 – Sox at Minnesota
  • April 16 – Sox at Minnesota
  • April 17 – Sox at Yankees
  • April 18 – Sox at Yankees
  • April 19 – Sox at Yankees
  • April 21 – Cleveland at Sox
  • April 22 – Cleveland at Sox
  • April 23 – Cleveland at Sox
  • April 24 – Kansas City at Sox
  • April 25 – Kansas City at Sox
  • April 26 – Kansas City at Sox
  • April 28 – Sox at Detroit
  • April 29 – Sox at Detroit
  • April 30 – Sox at Detroit
  • May 1 – Sox at Kansas City
  • May 2 – Sox at Kansas City
  • May 3 – Sox at Kansas City
  • May 4 – Sox at Kansas City
  • May 5 – Sox at Baltimore
  • May 6- Sox at Baltimore
  • May 7 – Sox at Baltimore
  • May 9 – Minnesota at Sox
  • May 10 – Minnesota at Sox
  • May 11 – Minnesota at Sox
  • May 12 – San Diego at Sox
  • May 13 – San Diego at Sox
  • May 14 – San Diego at Sox
  • May 15 – Sox at Anaheim
  • May 16 – Sox at Anaheim
  • May 17 – Sox at Anaheim
  • May 18 – Sox at Seattle
  • May 19 – Sox at Seattle
  • May 20 – Sox at Seattle
  • May 21 – Sox at Seattle
  • May 22 – Sox at Arizona
  • May 23 – Sox at Arizona
  • May 24 – Sox at Arizona
  • May 26 – Detroit at Sox
  • May 27 – Detroit at Sox
  • May 28 – Detroit at Sox
  • May 29 – Boston at Sox
  • May 30 – Boston at Sox
  • May 31 – Boston at Sox
  • June 2 – Sox at Detroit
  • June 3 – Sox at Detroit
  • June 4 – Sox at Detroit
  • June 6 – Sox at Tampa Bay
  • June 7 – Sox at Tampa Bay
  • June 8 – Sox at Tampa Bay
  • June 9 – Sox at Cleveland
  • June 10 – Sox at Cleveland
  • June 11 – Sox at Cleveland
  • June 12 – Baltimore at Sox
  • June 13 – Baltimore at Sox
  • June 14 – Baltimore at Sox
  • June 15 – Baltimore at Sox
  • June 16 – Sox at Toronto
  • June 17 – Sox at Toronto
  • June 18 – Sox at Toronto
  • June 20 – Sox at Minnesota
  • June 21 – Sox at Minnesota
  • June 22 – Sox at Minnesota
  • June 23 – Oakland at Sox
  • June 24 – Oakland at Sox
  • June 25 – Oakland at Sox
  • June 26 – Yankees at Sox
  • June 27 – Yankees at Sox
  • June 28 – Yankees at Sox
  • June 29 – Yankees at Sox
  • June 30 – Texas at Sox
  • July 1 – Texas at Sox
  • July 2 – Texas at Sox
  • July 3 – Sox at Oakland
  • July 4 – Sox at Oakland
  • July 5 – Sox at Oakland
  • July 7 – Sox at Colorado
  • July 8 – Sox at Colorado
  • July 9 – Sox at Colorado
  • July 11 – MLB All Star Game
  • July 14 – Seattle at Sox
  • July 15 – Seattle at Sox
  • July 16 – Seattle at Sox
  • July 18 – Los Angeles at Sox
  • July 19 – Los Angeles at Sox
  • July 21 – Sox at Kansas City
  • July 22 – Sox at Kansas City
  • July 23 – Sox at Kansas City
  • July 24 – Sox at Cubs
  • July 25 – Sox at Cubs
  • July 26 – Cubs at Sox
  • July 27 – Cubs at Sox
  • July 28 – Cleveland at Sox
  • July 29 – Cleveland at Sox
  • July 30 – Cleveland at Sox
  • July 31 – Toronto at Sox
  • August 1 – Toronto at Sox
  • August 2 – Toronto at Sox
  • August 3 – Sox at Boston
  • August 4 – Sox at Boston
  • August 5 – Sox at Boston
  • August 6 – Sox at Boston
  • August 8 – Houston at Sox
  • August 9 – Houston at Sox
  • August 10 – Houston at Sox
  • August 11 – Kansas City at Sox
  • August 12 – Kansas City at Sox
  • August 13 – Kansas City at Sox
  • August 15 – Sox at Los Angeles
  • August 16 – Sox at Los Angeles
  • August 17 – Sox at Texas
  • August 18 – Sox at Texas
  • August 19 – Sox at Texas
  • August 20 – Sox at Texas
  • August 21 – Minnesota at Sox
  • August 22 – Minnesota at Sox
  • August 23 – Minnesota at Sox
  • August 24 – Minnesota at Sox
  • August 25 – Detroit at Sox
  • August 26 – Detroit at Sox
  • August 27 – Detroit at Sox
  • August 29 – Sox at Minnesota
  • August 30 – Sox at Minnesota
  • August 31 – Sox at Minnesota
  • September 1 – Tampa Bay at Sox
  • September 2 – Tampa Bay at Sox
  • September 3 – Tampa Bay at Sox
  • September 4 – Cleveland at Sox
  • September 5 – Cleveland at Sox
  • September 6 – Cleveland at Sox
  • September 7 – Cleveland at Sox
  • September 8 – San Francisco at Sox
  • September 9 – San Francisco at Sox
  • September 10 – San Francisco at Sox
  • September 11 – Sox at Kansas City
  • September 12 – Sox at Kansas City
  • September 13 – Sox at Kansas City
  • September 14 – Sox at Detroit
  • September 15 – Sox at Detroit
  • September 16 – Sox at Detroit
  • September 17 – Sox at Detroit
  • September 19 – Sox at Houston
  • September 20 – Sox at Houston
  • September 21 – Sox at Houston
  • September 22 – Kansas City at Sox
  • September 23 – Kansas City at Sox
  • September 24 – Kansas City at Sox
  • September 25 – Anaheim at Sox
  • September 26 – Anaheim at Sox
  • September 27 – Anaheim at Sox
  • September 28 – Anaheim at Sox
  • September 29 – Sox at Cleveland
  • September 30 – Sox at Cleveland
  • October 1 – Sox at Cleveland